Innoculations are recommended for travel in Africa, especially for the first-time traveller. The following is taken mostly from the CDC website and from personal experience. Try to get your inoculations at least a week or two before leaving.
MMR (measles, mumps, rubella)
DPT (diphtheria, perussus,tetanus)
Malaria (antimalarial drugs) Needed for Kenya, not South Africa.
The following are a judgment call:
Yellow Fever (?)
S. Africa is not a malaria, yellow fever or polio zone.
You can get your shots all at once and have a sore shoulder for a day or so, but sometimes the clinic will be out of a particular vaccine, so it’s really best to take care of this at least a month out.
If you regularly take medicines be sure to bring enough along. There are good pharmacies in Cape Town for non-prescription and prescription drugs but you might want to bring along some aspirin and some general purpose cold tablets (sudafed variety) as well as bandaids and Tuff-skin for blisters. You can buy almost everything in Cape Town that you would find in the USA.
Note 1. YELLOW FEVER If you plan to travel from a yellow fever zone, to South Africa, you must have a yellow fever certificate or you will not be allowed to board the plane. If you plan to travel outside South Africa at all and re-enter you should get the yellow fever shots and TRAVEL WITH A COPY OF THE VACCINATION CERTIFICATE. Yellow Fever shots are expensive and painful and some US health care providers tend to routinely recommend them but they are not always necessary.
NOTE 2: MALARIA South Africa is not a malaria zone, particularly the Western Cape where we will be located.